The team of Professor WANG Xuechuan from SUST has made new progress in the field of Skin-Inspired Gelatin-Based Flexible Bio-Electronic Hydrogel scaffold materials

The team of Professor WANG Xuechuan from SUST has made new progress

in the field of Gelatin-Based Multifunctional Flexible conductive skin scaffolds materials

Author:LIU Xinhua

Release:LIU Guodong

Translator: HOU Yumo

The joint team of Professor WANG Xuechuan of the College of Bioresources Chemical and Materials Engineering of SUST and Professor GUO Junling of Sichuan University has recently made new progress in the field of collagen-based flexible conductive skin scaffolds, and related scientific research results have been published in the top international journal "Biomaterials" (IF=12.479). The research involves multidisciplinary fields, provides support for the non-tanning high-value applications of collagen, broadens the connotation development of our university's light industry disciplines, and further expands SUST's influence in the field of biomass functional materials.

In this paper, gelatin is used as raw material to construct a multifunctional bio-electronic flexible medical electronic skin. At present, tissue engineering scaffolds have problems such as relatively insufficient ability to promote tissue regeneration, single function, and poor interaction with cells. This study combines t intelligent and functional development trend with the basic concept of electrical stimulation to promote cell growth to construct a hydrogel scaffold (MESGel) with certain mechanical strength, electrical activity and self-healing properties, which can be used for electrical stimulation to promote wound healing and motion sensing. MESGel has excellent biocompatibility and multifunctional properties, including flexibility, self-healing properties, biodegradability and bioelectric activity. Comprehensive biological experiments have proved that the MESGel electronic skin scaffold can actively promote the proliferation of hamster lung epithelial cells through electrical stimulation, thereby induce skin wound healing, and provide an effective treatment strategy for the full-thickness skin defect model. In addition, MESGel can also be used as a new type of flexible electronic skin sensor to record the motion signal of the wound healing process in real time, which is expected to realize the integration of wound treatment and real-time monitoring. This research provides new ideas for the high-value resource utilization of biomass collagen and the construction of multifunctional medical stents, and has certain scientific research significance and application promotion value.


Ideas for constructing multifunctional electronic skin stents


Full-thickness skin defect model and immunological analysis of SPF rats

Related results were published on "Biomaterials" (2021, 121026, DOI: 10.1016/j.biomaterials.2021.121026) under the title of "Skin-Inspired Gelatin-Based Flexible Bio-Electronic Hydrogel for Wound Healing Promotion and Motion Sensing". SUST is the first communication unit of the paper. Doctoral student ZHENG Manhui is the first author, and the corresponding authors are Professor WANG Xuechuan, Associate Professor LIU Xinhua and Professor GUO Junling from Sichuan University.


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